Platelet Function Test - Anysis
Anysis System is a platelet function testing system that measures bleeding risk managing assessments, and anti-platelet therapy response assessments for inherited, acquired, or drug-induced platelet dysfunction. Through in-vivo vascular mimicking microfluidics, the system measures a realistic primary hemostasis associated with platelet function.
▶ Test Types
• Anti-platelet Therapy Response Assessment
• Bleed Risk Screening
Test Time: less than 5 minutes
The device includes two kit insertions which makes it possible to run two tests at a time.
Requiring blood sample: 200uL (sodium citrated)
▶ Key Features
1) Fully Automated System : With a single pipetting, the whole test is automatically operated
2) Bubble-free Test : Air bubbles in blood sample are naturally excluded in the test
3) Hematocrits-independent : Hematocrit variations do not affect the measurement of Anysis
4) Operator-independent Results : Measurements are not affected by operator's skillfulness
5) Stenosed Thrombosis Model : Flow through microbeads mimics stenosed vascular thrombosis
6) Platelet-adhesion Characteristic : Adhesion characteristic is fully emphasized in microscale pores
Upstream activation, which frequently occurs in pathological vascular environments, can be mimicked by adopting a shear-generating stirrer in a sample chamber.
After activation, the blood flows through a microfluidic tube including a flow-closure section consisted of ECM-coated microbeads. Typical ECMs are collagen and fibrinogen.
Downstream Adhesion of activated platelets occurs, followed by aggregation of platelets.
As the adhesion and aggregation of platelets continues, the flow paths through packed microbeads are gradually blocked and the blood flow eventually stops.
Measurement of how far the blood has migrated is the index for assessing the platelet function. The longer the distance migrated, the stronger the dysfunction of the platelets.