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Fraunhofer-Institut für Elektronische Nanosysteme ENAS

Technologie-Campus 3, 09126 Chemnitz
Germany

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This company is co-exhibitor of
IVAM Microtechnology Network: "High-Tech for Medical Devices" - Virtual Joint Pavillon

Contact

Dr. Mario Baum

Business Unit Manager »Technologies and Systems for Smart Health«
Department System Packaging

Phone
+49 371 45001-261

Email
mario.baum@enas.fraunhofer.de

Andreas Morschhauser

Head of Group Fluidic Integration and System Technology
Department Multi Device Integration

Phone
+49 371 45001-241

Email
andreas.morschhauser@enas.fraunhofer.de

Dr. Martina Vogel

Advisor to the Institutes Management, Head of Quality Management, Manager Marketing/PR

Phone
+49 371 45001-203

Email
martina.vogel@enas.fraunhofer.de

Dr. Bianca Milde

Technology Transfer Assistant / Strategic Coordinator

Phone
+49 371 45001-456

Email
bianca.milde@enas.fraunhofer.de

Dr. Christian Hedayat

Head of Department
Advanced Systems Engineering

Phone
+49 5251 60-5630

Email
christian.hedayat@enas-pb.fraunhofer.de

Franz Selbmann

Expert Parylene
Department System Packaging

Phone
+49 371 45001-491

Email
franz.selbmann@enas.fraunhofer.de

Dr. Nooshin Saeidi

Expert CMUT (Capacitive Micromachined Ultrasonic Transducers)
Department System Packaging

Phone
+49 371 45001-267

Email
nooshin.saeidi@enas.fraunhofer.de

Katja Meinel

Expert Piezoelectrical Sensors and Actuators for Medical Technology
Department Multi Device Integration

Phone
+49 371 45001-444

Email
katja.meinel@enas-extern.fraunhofer.de

Frank Roscher

Project Leader (APFEL and BeforeFever)
Department System Packaging

Phone
+49 371 45001-239

Email
frank.roscher@enas.fraunhofer.de

Toni D. Großmann

Projekt M3 Infekt

Phone
+49 371 45001-445

Email
toni.grossmann@enas.fraunhofer.de

Visit us

Unsettled / NN

16.11.2020

Topic

all-day

Arrange a live appointment with our contact persons via the matchmaking portal on the Networking Plaza!

18.11.2020

Topic

13:20 - 13:40

Presentation: Personalized Medical Treatments by Miniaturized Devices

Dr. Mario Baum
Business Unit Manager »Technologies and Systems for Smart Health«

Session: Microprecision, Manufacturing and Processing
at the virtual.COMPAMED HIGH-TECH FORUM 2020 by IVAM
Session link: https://youtu.be/BRz1dRmr7Vk

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Our range of products

Product categories

  • 02  Manufacturing of finished products
  • 02.15  In-vitro diagnostics (IVD)
  • 07  Microtechnology
  • 07.03  Microactors
  • 07  Microtechnology
  • 07.06  Microoptics
  • 07  Microtechnology
  • 07.08  Microprocessing
  • 07.08.02  Printed electronics

Printed electronics

  • 07  Microtechnology
  • 07.10  Nanotechnology

Nanotechnology

Our products

Product category: In-vitro diagnostics (IVD)

Project CovMoTe – Innovative mobile test system for the sustainable acceleration of SARS-Cov-2 detection and determination of immune status

In current corona pandemic situation, the high infectivity of the SARS-CoV-2 virus has shown to exceed the capacity of existing test resources for direct virus detection. A rapid and detailed mapping of the infection status in particularly vulnerable risk groups could greatly facilitate the implementation of countermeasures and containment of the pandemic. However, PCR test evaluation currently takes about 24 hours. In this Fraunhofer joint project (with Fraunhofer IME, ISIT, IBMT, EMFT and ENAS) a combined test system for the sustained acceleration of SARS-CoV-2 virus detection and existing immunity is developed, which can be used in mobile settings. This will make on-site testing of vulnerable risk groups easy to perform. The use of highly innovative techniques (neo-LAMP, electronic biochips) enables a test result within one hour for virus RNA detection. The addition of the immunity status to the test also allows a comprehensive assessment of the infection status. The Fraunhofer ENAS enables the decentralized performance of virus and immune detection by transferring the assay to their microfluidic platform together with the Fraunhofer ISIT.

Person in charge: Andreas Morschhauser

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Product category: Microfluidics

Project MOLOKO – novel sensor platform for enhanced food quality and animal health

Milk is seen as staple food and part of most people’s daily diet. Nevertheless, the prices for traditionally produced cow milk are constantly decreasing resulting in increasing economic pressure for milk farms. Thus, especially smaller milk producers try to produce high-value products either by ecological production, special properties (e.g. protein content) or other milk producing animals (e.g. buffalo or goat). Naturally, the achievable higher prices of these high-quality products also increase the chance of food fraud. Although analysis procedures for many food quality and safety parameters exist in the lab they are not suited to efficiently prevent food fraud because of the long and complicated analysis. In the H2020 Project MOLOKO (GA Nr.780839) a test system based on a novel plasmonic sensor is developed in order to enable rapid and onsite analysis of food quality and safety parameters of milk. In the consortium, Fraunhofer ENAS is developing a reusable microfluidic chip in order to enable a fast analysis.

Person in charge: Andreas Morschhauser

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Product category: Wearables

Project Sixth Sense – Micro needles for health monitoring of first responders

First responders are at the forefront of the fight for life and death. Extreme operations such as large-scale forest fires have developed from the exceptional to regularly events in the last decades. These operations often push rescue teams to their physical limits and beyond. In the European project SixthSense (GA No. 883315) a vital data monitoring system is being developed, which will indicate potentially critical health conditions to the first responders and control centers. The patch-like system is intended to provide noticeable feedback by means of electrostimulation.

The Center for Microtechnologies at Chemnitz University of Technology, supported by Fraunhofer ENAS, is developing polymer-based micro-needles, which will allow minimally invasive monitoring of vital parameters on the skin. The several hundred micrometer long needles are just long enough to extract interstitial fluid, but not long enough to hit blood vessels or pain receptors. Together with the European partners, a compact integration with biosensors for relevant parameters shall be achieved.

Person in charge: Andreas Morschhauser

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Product category: Wearables

Project BeforeFever – Wearable low cost thermometer for early indication of (SARS-CoV-2) virus infections

The body temperature is an essential indicator of the incidence of infection and can be used as an indicator of the incidence of illness 72 hours before the actual fever (38.1 ° C) occurs. The aim of the Fraunhofer ENAS project is to develop particularly cost-effective and easy-to-manufacture temperature sensors in the form of flexible wearables. The devices are intended to make a contribution to more effective patient monitoring outside of Intensive Care Units (ICUs). Especially for the surveillance of vulnerable population groups in institutions, but also in countries with comparatively poorly developed health care systems, the aim is to enable simple and particularly rapid initial indication of infections in the human body and monitoring of their course in a large number of the population.

Person of charge: Frank Roscher

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Product category: Research, Wearables

Project APFEL – Electronic wound patches for accelerated wound healing

Manufacturing and integration processes for active plasters are developed in the project. Through the integration of biocompatible electrode structures in wound dressings in combination with a corresponding activation and application of voltage, the cells are actively influenced during the healing process.

Fraunhofer ENAS develops special coating processes and material combinations for the production of robust electrically conductive electrodes on flexible substrates and develops simulation models for the calculation of the electric field strengths in heterogeneous dielectric ambient conditions.

Person in charge: Frank Roscher

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Product category: Wearables

Parylene for the encapsulation of medical implants and as a flexible substrate for wearables

Fraunhofer ENAS develops processes for the deposition of different Parylene types for the realization of a high quality thin film encapsulation of medical implants, MEMS, and organic electronics. The Parylene layers feature high conformity, biocompatibility according to ISO 10993, chemical inertness and optical transparency as well as the absence of intrinsic stress. In collaboration with the Fraunhofer FEP, an increase of the barrier properties of about several orders of magnitude was demonstrated successfully. Beside its application as an encapsulation, Fraunhofer ENAS develops ultra-thin, flexible electronics and sensors based on Parylene for the realization of wearables.

Person in charge: Franz Selbmann

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Product category: Microactors

Piezoelectric actuators and sensors for medical technology

Microsystems based on piezoelectric aluminum nitride (AlN) are developed at Fraunhofer ENAS. As an actuator and sensor material, AlN offers the advantage of a high miniaturization potential. The technical developments include AlN-based microscanners with integrated position sensors for one or two-dimensional deflection of laser beams for application in high-precision, endoscopic systems for medical technology. These include non-destructive imaging methods such as fluorescence microscopy or optical coherence tomography (OCT) for minimally invasive, endoscopic in vivo diagnostics.

Person in charge: Katja Meinel

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Product category: Microsensors

Fraunhofer Lighthouse Project »Theranostic Implants« - Hemodynamic controlling by implantable blood pressure measurement

Within the Fraunhofer Lighthouse Project »Theranostic Implants« technologies for future implants were developed by 12 Fraunhofer Institutes in close cooperation.
An implant for blood pressure measurement was developed by Fraunhofer IMS and ENAS. The overall system consists of a pressure sensor, an ASIC for data and energy management, an accelerometer for measuring the position of the patient and an interposer as a base, where the ASIC and the pressure sensor were developed by Fraunhofer IMS.
As a base of the system, an LTCC interposer with 75 μm line/space and 13 layers in a stack provided by NIKKO (JP) contains a coil for inductive energy supply and data transmission. The ASIC and the MEMS accelerometer are mounted onto the interposer either by flip-chip bonding using gold studbumps or by die attach and wire bonding.
Last but not least an Al2O3/Parylene thin film multi layer approach has been used for biocompatible and hermetic encapsulation. Finally the highly miniaturized system (length: 15 mm, diameter: 3 mm) is going to be proved after silicone encapsulation for functional operation together with Fraunhofer IMS.

Person in charge: Dr. Mario Baum

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Product category: Microsensors

CMUT - Capacitive Micromechanical Ultrasonic Transducer

Capacitive Micromachined Ultrasonic Transducer (CMUT) is a technology, based on silicon MEMS fabrication processes, for transmission and reception of ultrasonic waves. This technology has a number of advantages over the bulk piezo-based transducers. CMUTs can be highly miniaturized and integrated with their driving electronics; they have low acoustic impedance and wide bandwidth. One important characteristic of CMUTs is that their performance is stable over a large operating temperature.  With regard to the application areas, medical imaging is the mainstream application for CMUT, but this technology is finding its way to other domains (including material analysis, non-destructive testing, chemical sensing,…) as well.

Person in charge: Dr. Nooshin Saeidi

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Product category: Microsensors

Project SENS-O-SPHERES - Wireless power and data transmission for miniaturized measurement systems

The »Sens-o-Spheres« system uses miniaturized measuring balls to record process parameters such as temperature, pH value and dissolved oxygen concentration in the liquid of a bioreactor and transmits them to a processing basis station outside it, which monitors online the ongoing process in real time and adjusts it if necessary. In this project, the Fraunhofer ENAS developed a special radio-frequency communication system that is optimized for the small space available in the spheres (diameter of 8 mm) and guarantees a reliable radio link through the liquid to the basis station. In parallel, the ENAS has designed a new type of energy transfer interface, which enables the integrated rechargeable battery to be recharged regardless of the sphere position within the charging unit and thus allows the spheres to be reused up to 1000 times. Further project partners of this BMBF funded project are SAAS GmbH, e-nema GmbH, IMST GmbH, Ökoplast GmbH and the technical university of Dresden.

Person in charge: Dr. Christian Hedayat

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Product category: Microoptics

Project M3 Infekt - Continuously tunable optical filters

As a partner in the M3Infect consortium, Fraunhofer ENAS develops continuously tunable and thus wavelength-selective Fabry-Pérot filters (FPF) with large optical aperture for the visible spectral range from 450 nm to 700 nm. The goal is to com-bine these filters with a Vision-On-Chip (VSoC) system developed and provided by Fraunhofer IIS/EAS. The VSoC system is a software-programmable image sensor consisting of powerful camera hardware and flexible algorithms, enabling high frame rates and short response times with low power consumption. In combination with the FPF, a hyperspectral camera system is to be developed, which enables early detection and monitoring of patients suffering from COVID-19 by evaluating the temporally resolved hyperspectral image information. For example, respiratory rate, pulse, skin blood circulation or color changes of the skin can be evaluated, which allows conclusions about a possible COVID-19 disease. The hyperspectral camera system to be developed offers the advantage of a contactless early detection and monitoring possibility, which can be used in clinics, in medical offices, in elderly people’s homes and nursing homes or in their own residence. It is also possible to detect and monitor other infectious diseases that affect the skin, breathing rate or pulse at an early stage by using artificial intelligence.

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Company news

Date

Topic

Download

Nov 12, 2020

Fraunhofer ENAS presents a rapid virus test for the detection of the SARS-CoV-2 virus and an electronic wound patch to stimulate healing processes at virtual.COMPAMED 2020

Get a proof of infection with the SARS-CoV-2 virus or of immunity to the virus within one hour. Accelerate healing processes with electrical stimulation through an active wound patch. Fraunhofer ENAS will present these and other topics for the first time from November 16-19 at the digital medical technology trade fair virtual.COMPAMED 2020.

At this year's digital medical trade fair virtual.COMPAMED, the Fraunhofer Institute for Electronic Nano Systems ENAS will be presenting, among other things, projects designed to help contain the current CORONA pandemic. Visitors to virtual.COMPAMED can obtain information online at the exhibitor portal and can enter into discussions with the experts live via chat or video call at the trade fair platform www.compamed.de from November 16-19, 2020.

Test system for rapid SARS-CoV-2 virus detection
The Fraunhofer-Gesellschaft has initiated a number of projects with the action program »Fraunhofer vs. Corona«, which are intended to help fight against the current pandemic. At virtual.COMPAMED, Fraunhofer ENAS will present one of these projects under the title »CovMoTe«. Since the high infectivity of the SARS-CoV-2 virus exceeds the current capacities of the available test resources for direct virus detection, the search is on for methods that provide a fast and detailed picture of the infection status. In the joint Fraunhofer project CovMoTe, Fraunhofer ENAS is working together with the Fraunhofer Institutes IME, ISIT, IBMT and EMFT on the development of a mobile combined test system for the sustained acceleration of the SARS-CoV-2 virus detection and the proof of existing immunity. The use of highly innovative techniques (neo-LAMP, electronic biochips) enables a test result within one hour for virus RNA detection. The addition of the immunity status to the test also allows a comprehensive assessment of the infection status. Fraunhofer ENAS, together with Fraunhofer ISIT, enables the decentralized performance of virus and immune detection by transferring the assay to their microfluidic platform.

Active electronic wound patch for stimulating cells
Besides other CORONA-related projects, the institute presents developments in the field of micro sensor and actuator technology for medical technology, microfluidic systems, materials for medical products and wearables. For active wound plasters with electrical stimulation, Fraunhofer ENAS developed special coating processes and material combinations for the production of robust electrically conductive electrodes on flexible substrates. Simulation models for calculating the electric field strengths in heterogeneous dielectric ambient conditions were also developed. The integration of biocompatible electrode structures in wound dressings in combination with a corresponding activation and application of voltage actively influenced the cells during the healing process.

Wireless power transmission for measurement technology in bioreactors
In the field of measurement technology and analytics, the institute presents the »Sens-o-Spheres« measurement system, a joint development of TU Dresden, SAAS GmbH, e-nema GmbH, IMST GmbH, Ökoplast GmbH and Fraunhofer ENAS, funded by the BMBF. The system records process parameters in bioreactors using measuring spheres. In a sub-project, Fraunhofer ENAS developed a communication system specially optimized for the inside of the spheres and an interface for wireless energy transmission for recharging the batteries independent of their position. In combination with an intelligent control of each energy-transmitting coil, a high charging coverage for the complex system could be achieved for the simultaneous charging of several sensors.

Materials for medical devices and implants
Another focus of the presentation is on materials used for micro sensors, actuators and for encapsulating systems. Fraunhofer ENAS develops microsystems based on the piezoelectric material aluminum nitride (AlN). As actuator and sensor material, AlN offers the possibility of a high degree of miniaturization to enable the further development of micro scanners for high-precision endoscopic systems. For biocompatible encapsulation, Fraunhofer ENAS relies on the polymer material Parylene. The institute develops processes for the deposition of different types of Parylene for high-quality thin-film encapsulation of medical implants, MEMS and organic electronics. The Parylene layers are characterized by high conformity, biocompatibility according to ISO 10993, chemical inertness and optical transparency and are free of internal mechanical stress.

These and further developments can be found online on the internet portal www.compamed.de. With a free registration, visitors of virtual.COMPAMED can also attend live presentations and enter into direct discussions with the experts in the matchmaking portal from November 16-19, 2020.

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Nov 5, 2020

Decentralized monitoring of COVID-19 patients: M3Infekt project launched

Fraunhofer ENAS contributes its expertise on continuously tunable Fabry-Pérot filter for a monitoring system of COVID-19 patients within the Fraunhofer cluster project M3Infekt. The cluster project aims to develop a monitoring system that enables early intervention in the event that a patient’s condition suddenly starts to deteriorate. It will be a modular, multimodal and mobile system, and will also be suitable for use in the treatment of COVID-19 patients. By facilitating the required intervention at an early stage, the system helps to lessen the effects of disease, shorten the duration of therapy and make flexible use of intensive care wards.

Quick and reliable diagnosis of disease progression
The coronavirus pandemic poses a challenge for medical diagnostics. Alongside serious cases, the SARS-CoV2 virus also causes mild symptoms, but these can very quickly worsen. Currently, however, continuous patient monitoring is available only on intensive care wards. When someone’s health suddenly deteriorates, there is often some delay to this being recognized, meaning the patient is taken to hospital too late. This is precisely where the M3Infekt cluster project comes in. Using various technologies, the mobile system acquires, analyzes and fuses relevant biosignals, which enables a valid diagnosis to be made of the patient’s condition and the progression of the disease.
The idea is to provide a long-term solution for decentralized monitoring of patients on normal wards and in non-hospital environments using multimodal parameters of the cardiovascular system (including heart rate, ECG, oxygen saturation, blood flow) and respiratory parameters (including respiratory rate/volume, breath analysis). Machine learning methods serve as the basis for evaluating these parameters, facilitating diagnosis and enabling integration of the system into different deployment and application scenarios, regardless of location.

Affordable healthcare benefits patients and health services
The planned system has a modular and mobile structure with standardized, open interfaces. These enable easy integration into other platforms and make the system suitable for use with various diseases, including influenza, pneumonia and sepsis. It will enable continuous monitoring, previously used only for patients in intensive care, to be rolled out to non-hospital scenarios, such as short- and long-term care, outpatient treatment or home settings. This way, patients can remain in a favorable environment and move to a hospital only if their condition suddenly deteriorates.

Fraunhofer IIS is the project lead in the M3Infekt consortium, which comprises ten Fraunhofer Institutes and four medical partners. Together, they form an interdisciplinary group built on complementary areas of expertise. The M3Infekt project is funded as part of the Fraunhofer-Gesellschaft’s internal programs.

Partners:
Fraunhofer Institute for Integrated Circuits IIS
Fraunhofer Institute for Integrated Circuits IIS, Division Engineering of Adaptive Systems EAS
Fraunhofer Institute for Photonic Microsystems IPMS
Fraunhofer Institute for Ceramic Technologies and Systems IKTS
Fraunhofer Institute for Electronic Nano Systems ENAS
Fraunhofer Institute for High Frequency Physics and Radar Techniques FHR
Fraunhofer Institute for Nondestructive Testing IZFP
Fraunhofer Institute for Structural Durability and System Reliability LBF
Fraunhofer Research Institution for Microsystems and Solid State Technologies EMFT
Fraunhofer Project Hub for Microelectronic and Optical Systems for Biomedicine MEOS

Clinical partners:
Klinikum Magdeburg
Charité – Universitätsmedizin Berlin
Universitätsklinikum Erlangen
Universitätsklinikum Dresden

Contact:
Dr. Christian Münzenmayer (Fraunhofer IIS)
Dr. Michael Scholles (Fraunhofer MEOS)

Continuously tunable optical filters as a development contribution of Fraunhofer ENAS
As a partner in the M3Infect consortium, Fraunhofer ENAS develops continuously tunable and thus wavelength-selective Fabry-Pérot filters (FPF) with large optical aperture for the visible spectral range from 450 nm to 700 nm. The goal is to com-bine these filters with a Vision-On-Chip (VSoC) system developed and provided by Fraunhofer IIS/EAS. The VSoC system is a software-programmable image sensor consisting of powerful camera hardware and flexible algorithms, enabling high frame rates and short response times with low power consumption. In combination with the FPF, a hyperspectral camera system is to be developed, which enables early detection and monitoring of patients suffering from COVID-19 by evaluating the temporally resolved hyperspectral image information. For example, respiratory rate, pulse, skin blood circulation or color changes of the skin can be evaluated, which allows conclusions about a possible COVID-19 disease. The hyperspectral camera system to be developed offers the advantage of a contactless early detection and monitoring possibility, which can be used in clinics, in medical offices, in elderly people’s homes and nursing homes or in their own residence. It is also possible to detect and monitor other infectious diseases that affect the skin, breathing rate or pulse at an early stage by using artificial intelligence.


Person in charge:
Toni D. Großmann (Fraunhofer ENAS)
Phone +49 371 45001-445
toni.grossmann@enas.fraunhofer.de

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About us

Company details

The Fraunhofer Institute for Electronic Nano Systems ENAS combines the business unit »Technologies and Systems for Smart Health« R&D activities with applications in the field of health and life sciences.
Our research is focused on the technical and technological aspects, especially in using micro and nanotechnologies for applications in the service of medical science, biology, and healthy living.
This business unit is focusing especially on:
  • Implants
  • Medical devices
  • Microfluidic and spectroscopic analysis

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Company data

Number of employees

100-499

Foundation

2008

Area of business

Services

Company information as a PDF file