SELco® TRAb human 1 step is a sensitive radioimmunoassay for the detection of TSH receptor antibodies.
Compared to the classical two-step assay, the incubation time is shortened to 120 minutes in one step only.Your advandtages at a glance:
- Only 120 minutes incubation time
- One step Assay
- Suitable for automated processing
- Calibration based on the international reference standard WHO-08/204 (2nd International Standard for Thyroid Stimulating Antibody)
SELco® TRAb human 1-step is a competitive radio receptor assay (RRA). During the incubation step the TSH receptor autoantibodies (TRAb) of the patient samples or calibrators compete with iodinated monoclonal antibodies (Tracer) to TSH receptor for the immobilized TSH receptor on the solid phase of coated tubes.
The level of the measuring signal is inversely proportional to the TRAb concentration in the tested samples and can be read off from a calibrator curve with known TRAb concentrations.Scientific Background
Graves' disease is an autoimmune disease of the thyroid gland. In this disease the body's own defense cells form antibodies against receptors of the thyroid cells, resulting to increasinged production of thyroid hormones, known as hyperthyroidism. The consequences are numerous disorders, such as tachycardia or cardiac arrhythmia, weight loss amidst ravenous appetite, restlessness and nervousness.The determination of the TSH receptor antibodies (TRAb) is a major step in the diagnosis of Graves' disease.