Biocatalysts Ltd, based in Cardiff, Wales, UK and part of Germany-based BRAIN group, are an experienced biotechnology and manufacturing company, that produces speciality enzymes at commercial scales for a variety of industries, such as life science, diagnostics, pharma and fine chemicals. We offer both off-the-shelf enzyme products and a customised enzyme discovery, development and contract manufacturing service.
The traditional method is the Guthrie microbial test but this is being replaced by a cheaper and more rapid and sensitive enzyme test based on phenylalanine dehydrogenase which has proved sensitive, reliable and rapid compared to other methodologies. Low cross reactivity results in lower false positives than the Guthrie and fluorometric methods.
Product category: Other molecular diagnostics testing
Proteocut K (PK909L)
Proteocut K (PK909L) is a subtilisin-type serine protease with a broad substrate specificity that can be used in a wide variety of life science applications, such as to hydrolyse proteins in nucleic acid preparations. The enzyme is completely deactivated at a temperature of 80°C for 6 minutes.
Proteocut K (PK909L) has been designed as an alternative to liquid Proteinase K and can be used in the following applications:
Enzyme based test methodologies are ideal for diagnostic applications and are easy to carry out, sensitive and reliable. Mannitol Dehydrogenase (ManDH) is active against mannitol and is therefore useful for its determination. When present in the urine, (and relative to other components) mannitol is a good indicator of gastric disorders. Other diagnostic options such as biopsy are not so patient friendly.
Biocatalysts Ltds Commercial Director, Daren Bryce takes you through our enzyme discovery and manufacturing process including the new, on-site, enzyme manufacturing facility. It has been a challenging project for Biocatalysts to undertake the design and build of a new manufacturing facility, but it has been worth it. We are proud to have a truly market leading biotechnology facility, that is based on LEAN operating principles. At the core of our new plant is a 10,000L fermenter and its supporting network of seed, feed and process vessels. This is supported by bespoke designed cutting-edge equipment ensuring our scale-up is as reliable and robust as possible.
2020 - A Year When Everything Changed for Molecular Biology!
Molecular biology as a field of science has been around since the mid 1900s when the work of classical genetics converged with the work of physicists and structural chemists to develop these initial theories of how cells function and communicate. Author: Carolyn Pritchard Role: Technical Marketing Manager
Our proprietary MetXtra™ platform allows us to rationally and rapidly identify completely novel enzymes from large metagenomic libraries and databases. This includes our very own metagenomic libraries that have been sourced from diverse environmental niches such as hot/cold, acid/alkaline and saline. The results are filtered through numerous algorithms within MetXtra™ to refine the candidate enzyme list. Refinement encompasses customer specifications and requirements, such as solubility, pH and temperature, so that the final enzyme panel is targeted specifically to their needs. This rational selection process ultimately gives fast, low cost access to enzymes with a higher probability of being commercially successful.
Biocatalysts Ltd is a global biotechnology company part of the BRAIN group, that produces speciality enzymes at commercial scales for a variety of industries, such as life science, diagnostics, pharma and fine chemicals. We offer both off-the-shelf enzyme products and a customised enzyme discovery, development and contract manufacturing service. Contact us to discuss what we have to offer and how we can help you achieve your enzyme solutions.
Biocatalysts Limited Unit 1, Cefn Coed, Parc Nantgarw, Cardiff CF15 7QQ Wales, UK